Validation Data

Dosimetric Benchmark Tables

Detailed DVH metrics, plan quality scores, and OAR dose comparisons from Airato's internal validation cohort. All data represents retrospective plan comparison against clinical-approved reference plans.

Data Disclosure Note: All benchmark data on this page derives from Airato's internal retrospective validation study — not from externally peer-reviewed publications. Plans were re-optimized using Airato and compared to clinical-approved reference plans from participating departments. These numbers characterize Airato's dosimetric performance for evaluation purposes; they do not constitute a clinical claim or external validation.

Study Design

Retrospective plan comparison. CT image sets, contours, and approved reference plans from participating radiation oncology departments in Japan. Airato re-optimized each case using the same prescription and OAR constraints as the reference plan.

No patient treatment was modified. Airato plans were compared to reference plans on dosimetric metrics only.

Cohort Composition

15 IMRT cases across three treatment sites: prostate (6 cases), head-and-neck (5 cases), lung (4 cases). Mixed prescription doses per site standard institutional protocols.

Evaluation Metrics

Primary metrics:

Plan Quality Metric (PQM) — composite score
D95 for PTV — target coverage
Dmean for principal OARs per site
Dmax for serial OARs (spinal cord, brainstem)
V20 for bilateral lung (lung cases)

Comparison: Airato plan vs. clinical-approved reference plan. Values reported as mean ± SD across cohort.

Prostate IMRT (n=6)

DVH Metric	Reference Plan (Mean ± SD)	Airato Plan (Mean ± SD)	Difference
PTV D95 (%)	95.6 ± 1.1	96.2 ± 0.8	+0.6%
PQM Score	87.4 ± 4.2	94.2 ± 3.1	+6.8 pts
Rectum Dmean (Gy)	32.4 ± 5.1	24.8 ± 4.3	−7.6 Gy
Bladder Dmean (Gy)	28.1 ± 6.8	22.3 ± 5.4	−5.8 Gy
Femoral Head Dmean (Gy)	14.2 ± 3.3	12.1 ± 2.8	−2.1 Gy

Head & Neck IMRT (n=5)

DVH Metric	Reference Plan (Mean ± SD)	Airato Plan (Mean ± SD)	Difference
PTV D95 (%)	94.9 ± 1.8	95.4 ± 1.2	+0.5%
PQM Score	85.1 ± 5.6	92.7 ± 4.1	+7.6 pts
Spinal Cord Dmax (Gy)	43.2 ± 3.4	38.6 ± 2.9	−4.6 Gy
Parotid (ipsi) Dmean (Gy)	28.4 ± 7.2	21.8 ± 5.8	−6.6 Gy
Mandible Dmean (Gy)	35.6 ± 8.1	30.2 ± 6.7	−5.4 Gy

Note: These data are from a small retrospective cohort for characterization purposes. Mean ± SD computed across n=5–6 cases per site. Statistical significance testing not reported due to small sample size. Full validation report available under NDA. See Clinical Evidence overview for methodology details.

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Full methodology and case-level data available under NDA for clinical evaluators.

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