Platform Module 02
DVH-Constrained Multi-Criteria Dose Optimization
Airato's dose optimization solver minimizes OAR dose while maintaining PTV coverage objectives. Constraint satisfaction is visible per structure throughout the optimization process.
DVH Constraint Architecture
The Dose Optimization module accepts a set of DVH constraints for each structure: the PTV (target coverage goals) and all defined OARs (dose limits and mean dose objectives). Constraints are specified in standard clinical terms — D95 for PTV, Dmax for spinal cord, Dmean for parotids — and mapped internally to the optimization objective function.
The multi-criteria weighted-sum approach balances competing constraints. When all constraints cannot be simultaneously satisfied, the system presents a Pareto-front sampling allowing the physicist to choose the clinical trade-off explicitly.
Constraint satisfaction status is displayed per structure in real time during optimization, not only at completion. This allows early identification of unsatisfied constraints before full optimization convergence.
Optimization Engine Overview
Multi-Criteria Optimization
Weighted-sum objective function balances PTV coverage against OAR dose objectives. Weights are adjustable by the physicist within clinical constraint bounds.
Transparent Constraint Status
Per-structure constraint satisfaction displayed during optimization iterations. Green/amber/red status for each structure's DVH metric against its objective.
QUANTEC-Aligned Constraint Libraries
Default OAR constraint libraries aligned with published QUANTEC tolerance dose guidelines. Site-specific constraint sets can be customized per institutional protocol.
Internal Validation Cohort Results
Dosimetric benchmarks from Airato's internal validation cases. Data represents performance on characterized treatment sites; not from external peer-reviewed publication.
Plan Quality Metric in validation cohort. Higher is better; institutional reference typically ≥85.
Compared to conventional planning for equivalent PTV coverage, internal validation cohort.
Target coverage objective met in ≥97% of validation cases when constraints permit.
Review DVH optimization with your constraint set.
Bring your institutional OAR constraints to a clinical demonstration session.